Thursday, May 31, 2007

HealthExtras (HLEX): Underappreciated PBM with Best Model

by Alan J. Brochstein, CFA
Analyst For Hire



When investing in Healthcare, which I believe is one of the most attractive growth industries, I am always looking to find companies that take cost out of the system. I have long believed that Pharmacy Benefits Managers (PBMs) are one of the better ways to fulfill that goal. At my former employer, we were long ESRX from 2000 until late 2005. One of the things that always disturbed me was the black-box element: How EXACTLY did these PBMs make their money. Often, they were accused by their customers or state governments of misrepresentation and other crimes. Cutting through all of the politics involved, it is clear that there were (and still are) significant “gray areas”. I always appreciated Barrett Toan, the former CEO of ESRX, for his leadership in the industry. Under his watch, the company walked away from some business that was in conflict with the best interests of the company’s clients. While almost everyone is familiar with the “Big Three”, MHS, ESRX and CVS (Caremark), I don’t think that investors appreciate the unique model of HealthExtras (HLEX) (30.50, $1.3 billion market capitalization, S&P 600 member).

I first came across HLEX in early 2006 when they won an absolutely stunning deal, taking away a client (Wellmark) from one of the Big Three. The stock ran up, as you can see in the chart below (to an unsustainable valuation), on that news and then consolidated for quite some time. The company has renewed two large contracts and won another competitive situation (Maryland) in that time. The stock has been in bull mode since Louisiana was re-awarded and Maryland’s implementation delay ended in Q1.


So, what makes HLEX different from other PBMs? First, their interests are more aligned with the customers. They don’t operate a mail-order facility for profit (though they do offer mail-order via CVS or WAG). Their transparency is quite evident in other ways as well. Second, they tend to think locally, which is very different from the Big Three. They understand well that healthcare is a local service, and they customize their products in the geographies they serve. They tend to get very large concentrations in these localities, and they, unlike the other PBMs, are able to truly offer meaningful web interaction with the plan members. Their transparency and service levels get them very high ratings from their customers relative to their larger peers. The proof, though, is in their retention and competitive take-aways. The final difference is their size. I believe that due to the superiority of its model, increasing concerns about the lack of transparency at the Big Three and its relatively small size, this company could really grow.

Financially, HLEX has expanded very rapidly, sinking a lot of up-front cost into bring new clients on board (without any hitches, I might add). Their balance sheet remains much stronger than others in the industry (and requires less capital as the company doesn’t buy drug inventory for speculative purposes). Unlike their two pure-play peers, they have some tangible capital and no debt at all. Earnings estimates were dinged primarily by the Maryland delay, but they are increasing again. EPS growth in 2008 is expected to be 25% on top of 36% growth this year. EPS growth the past 3 years has been 36%. Future growth will come from further large contract wins, geographic expansion and their entry into a few new markets (Third-Party Administrators and Brokers, Worker’s Comp and Labor Unions).


I believe that HLEX could trade to 39 later this year based upon attaining a 30 PE (on the 2008 estimate). As you can see from the chart below, valuation is at median levels despite the many changes that have taken place. First of all, the company has successfully implemented some very large contracts. Second, consolidation should bode well for this company. Finally, the market cap is now at a level that the company should command the attention of small-cap investors. In my opinion, this company is the “safest” it has ever been, with large implementations behind them, big opportunities ahead and an environment that favors their business model of transparency. A final thought is that this company should command a premium for its lack of exposure to Medicare reimbursement.


Disclosure: Author and members of his family are long HLEX

Source: AnalystForHire.com




BioHealth Investor.com
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Telemedicine Addresses Rising Healthcare Costs

by Sara Calabro
Med Tech Sentinel



A recent article in The New York Times discusses TeleStroke, a telemedicine program being offered by Brigham and Women’s and Massachusetts General Hospitals in Boston. The program is designed to help hospitals that do not have the resources to employ expensive stroke specialists and as a result, are not equipped to make decisions about administering the effective but high-risk standard-of-care medicine for stroke, tPA.

Through TeleStroke, stroke specialists can examine and diagnose patients remotely via videoconferencing and image-sharing technology. Hospitals pay an annual fee ($10,000 in the case of Martha’s Vineyard Hospital, the focus of the Times piece) for 24-hour virtual access to stroke specialists. The fee is miniscule in comparison to keeping on staff highly trained physicians who command steep salaries.

Telemedicine companies are popping up everywhere. Earlier this month, at the American Telemedicine Association’s annual meeting, more than 300 presentations took place on remote care, computer-assisted diagnoses, robotics and other telemedicine topics.

One exhibitor at the event, TeleMedDox, has a similar offering to TeleStroke’s, but on a specialty-wide basis. The privately held Sarasota, FL-based company provides contract physician services to corporations, private practices and government agencies. Through a pocket-sized key drive, credentialed physicians in TeleMedDox’s network can access and share medical records, lab results and diagnostic images. The company also offers one-on-one, real-time sessions with physicians (through videoconferencing).

In addition to rising healthcare costs, TeleMedDox’s technology may help address another systemic problem: physician frustration with long, inconvenient schedules and insurance headaches.



BioHealth Investor.com
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Thursday's Top Biotech & Medical Stocks

by H.S. Ayoub
BioHealth Investor.com



Biotechnology

PEREGRINE PHARMA INC [PPHM] +36.27%
DENDREON CORP [DNDN] +26.86%
CRITICAL THERAPEUTIC [CRTX] +21.39%
3SBIO INC [SSRX] +18.38% $0
VION PHARM INC [VION] +10.63%



Diagnostic Substances

PONIARD PHARMA [PARD] +14.17%
REMOTEMDX INC [RMDX.OB] +6.67%
IMMUNOMEDICS INC [IMMU] +6.18%
EPICEPT CORPORATION [EPCT] +5.65%
SYNTA PHARMACEUTICAL [SNTA] +5.05%



Drug Delivery

INSITE VISION INC [ISV] +11.18%
DELCATH SYSTEMS INC [DCTH] +7.49%
BIOPROGRESS PLC [BPRG] +5.08%
NOVEN PHARMACEUTIC [NOVN] +4.64%
ELAN CP PLC ADR [ELN] +2.98%



Drug Manufacturers

PHARMACYCLICS INC [PCYC] +16.10%
ALEXZA PHARMACEUTICA [ALXA] +9.01%
PRANA BIO LTD ADS S1 [PRAN] +9.00%
DYNAVAX TECHNOLOGIES [DVAX] +8.97%
AVANIR PHARMACEUTICL [AVNR] +7.45%



Drug Related Products

IMAGENETIX INC [IAGX.OB] +8.33%
NUTRACEUTICAL INTL [NUTR] +4.01%
ARGAN INC [AGAX.OB] +4.00%
NATURAL ALTERNATIV [NAII] +2.11%
PACIFICHEALTH LABS [PHLI.OB] +1.92%



Generic Drugs

ISOLAGEN INC [ILE] +17.27%
CATALYST PHARMACEUTI [CPRX] +8.54%
CARACO PHARMA LABS [CPD] +3.34%
PHARMACUTICAL CO [PRX] +0.72%
BARR PHARMA INC [BRL] +0.66%



Medical Appliances & Equipment

LECTEC CORP [LECT.OB] +35.42%
SONTRA MEDICAL CORP [SONT.OB] +12.00%
ROCKWELL MED TECHS [RMTI] +11.23%
ENDOCARE INC [ENDO.OB] +7.46%
PATIENT SAFETY TECH [PSTX.OB] +7.14%



Medical Instruments & Supplies

ARISTOTLE CP [ARTL] +16.31%
OCCULOGIX, INC. [OCCX] +15.84%
ELECTRO-OPTICAL SCIE [MELA] +14.43%
RETRACTABLE TECH INC [RVP] +12.92%
STEN CORPORATION [STEN] +6.68%



Medical Laboratories & Research

SPHERIX INC [SPEX] +4.14%
GENOMIC HEALTH, INC. [GHDX] +2.67%
PHARM PROD DEV [PPDI] +1.53%
ERESEARCHTECHNOLOG [ERES] +0.90%
OSI PHARMACEUTIC [OSIP] +0.83%




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Dendreon Catches a Break From The FDA

by Jon C. Ogg
24/7 Wall St.


Dendreon (DNDN) is benefitting from something that become thought of as a low probability event: an FDA that buckled at least a little to peer pressure. It has received confirmation that the FDA will accept either "a positive interim or final analysis of survival" from its ongoing IMPACT study to amend the Biologics License Application for PROVENGE as a late-stage prostate cancer treatment. This information was obtained in a recent follow up meeting with the FDA to discuss the additional clinical data required to support the licensure of PROVENGE requested by the FDA in the Complete Response Letter the Company received on May 8, 2007.

Mitchell H. Gold, President/CEO: "We anticipate completing enrollment in the IMPACT study this year and anticipate interim survival results in 2008. We are committed to making PROVENGE available as rapidly as possible to help the many men with late-stage prostate cancer who currently have few appealing treatment options." So the translation here is that this won't yield an immediate approval, but it could move up the date of an approval considerably.

Continue article at 247WallSt.com



RELATED READING:
- Dendreon Volume and Volatility Compress Ahead of ASCO
- Dendreon Interest Remains Extremely High
- Dendreon's New Double-Twist
- Rantasorous Rx
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Biotechs & Pharmas Bracing For ASCO Annual Meeting

by Jon C. Ogg
24/7 Wall St.



This weekend we have the mother of all future cancer treatment conferences: ASCO, or The American Society of Clinical Oncology. Cancer stocks in the last few weeks have been seeing a muted response ahead of the event that biotech investors have traditionally braced for. At various points on the website you can find a full list of contributing and presenting companies. This is only a sample of the companies presenting data and it is very possible that the dates and even the companies may have changed. Also, you’ll probably start seeing news here at this ASCO News Site either late Thursday evening or Friday. Some of these dates and presentation schedules have been compiled over a multi-week period, so it is very likely that some of these will have changed.


SATURDAY, JUNE 2

Genentech (DNA) will show data with Roche on Avastin plus a chemotherapy dual-mix cocktail for first line treatment in non-small cell lung cancer patients. Later on at ASCO, a failed Avastin study for the treatment of pancreatic cancer will be shown. Some Phase III Avastin data in kidney cancer will also be presented next week. Genentech will also be showing data with partners OSI Pharmaceuticals (OSIP) and Imclone (IMCL) in later days.

Pfizer (PFE) will present data on Sutent’s safety and efficacy in Phase II liver cancer studies.

If you forgot about Dendreon (DNDN), this will be the company’s last known data presentation on Provenge after getting the FDA delay. Investors will be looking closely at any ‘New Data’ presented because much of the ongoing study data is being treated as old data.

Arqule (ARQL) and Exelixis (EXEL) are presenting data as well on molecules that are deemed cancer targets.


Continue article at 247WallSt.com



RELATED READING:
- Dendreon Volume and Volatility Compress Ahead of ASCO
- Cancer Stocks on the Go: It’s ASCO
- BioWatch Alert: ArQule Could See 15% Gain Ahead of ASCO
- Is Early Release of Study Data to Doctors Unfair?

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Wednesday, May 30, 2007

BioHealth Investor Looking for Contributors & Writers

by H.S. Ayoub, DMD
BioHealth Investor.com



BioHealth Investor.com, the leading business blog for the medical and biotechnology industry is looking for writers and bloggers to contribute exclusive content.

BHI is offering contributors 50% of Google Ad revenue from their posts, and reciprocal links back to their sites of choice.

For more information please visit:
http://biohealthinvestor.com/contributor.html




Source: BioHealth Investor.com

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BioSpace.com Running BioHealth Investor's Feed!

by H.S. Ayoub, DMD
BioHealth Investor.com



I noticed today that over the last few days traffic has been pouring in to BioHealth Investor from BioSpace.com, the leading portal for the biotechnology industry.

I visited BioSpace and noticed that BHI's feed is now running on its homepage under the blogs section. Many thanks to BlogBurst, the blog broker for hooking that up.

BHI's content is now featured by Yahoo!Finance, Google Finance, SeekingAlpha.com, TheStreet.com, 247WallSt.com, TheMoneyBlogs.com, and now BioSpace.com, not to mention the hundreds of other blogs and sites that link here.

Thanks to all the editors, contributors and readers that have made BHI the leading blog for the medical and biotech industry.



Source: BioHealth Investor.com

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FDA Green Lights Harvest’s Stem Cell Trial

by Sara Calabro
Med Tech Sentinel



Harvest Technologies, a Plymouth, MA, company that uses stem cells from bone marrow to treat critical limb ischemia, received the go-ahead yesterday from FDA to start a 48-patient trial for the company’s Bone Marrow Aspirate Concentrate (BMAC) System. If all goes as planned, Harvest expects the device to hit the market sometime in 2010.

The BMAC System concentrates a patient’s bone-marrow stem cells in approximately 15 minutes, then injects them into the affected limb to reduce the likelihood of amputation. Critical limb ischemia is a late-stage form of Peripheral Arterial Disease, which involves clogged arteries — commonly in the legs — that can result in toe or feet amputation. The thinking behind the BMAC device is that the injection of stem cells will arrest and possibly reverse the effects of critical limb ischemia.

In a European pilot study of BMAC, 23 patients with ischemic legs who were threatened by amputation were injected with their own bone-marrow stem cells; 16 (70 percent) were able to avoid amputation.

Following yesterday’s IDE approval, Harvest Technologies’ president, Gary Tureski, told The Patriot Ledger that BMAC’s ability to quickly identify and concentrate stem cells that aid in the creation of new blood vessels is what makes it superior to other technologies that use bone-marrow stem cells in a similar way. Harvest’s device is unique, according to Tureski, because a doctor can complete the whole process in one sitting, while other systems rely on shipping the bone marrow off-site for the concentration process, requiring a patient to make more than one trip to the doctor’s office.

“We do it right at the bedside, right at the point of care,’’ Tureski told the paper. ‘‘The whole procedure can be done in less than an hour.’’



RELATED READING:
- Key Stem Cell Patents Revoked
- Stem Cell Stocks Gain On British Study, Geron Gives Some Back
- Osiris: Promising Stem Cell Research, Questionable Management
- At Home Guide to Isolating Amniotic Stem Cells from Placentas!

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Novacea and Schering-Plough Prostate Cancer Pact

by Jon C. Ogg
24/7 Wall St.



Novacea (NOVC) is seeing its shares up more than 70% after signing a pact with Schering-Plough (SGP) over the development and commercialization of Asentar for the treatment of prostate cancer. Novacea will receive an upfront payment of $60 million, including $35 million as reimbursement for past research and development expenses, a license fee of $25 million, as well as a commitment by Schering-Plough to purchase $12 million of Novacea common stock at a predetermined price within ten days of the closing. Additionally, the agreement provides Novacea with potential pre-commercial milestone payments of up to $380 million, and tiered royalties on worldwide sales of Asentar.

Novacea is currently conducting a large international Phase 3 trial evaluating Asentar in 900 patients with androgen-independent prostate cancer.

Continue article at 247WallSt.com


RELATED READING:
- Cancer Stocks on the Go: It’s ASCO
- BioWatch Alert: ArQule Could See 15% Gain Ahead of ASCO
- Is Early Release of Study Data to Doctors Unfair?

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Mini-meds mandated in Massachusetts?

by David E. Williams
Health Business Blog



Massachusetts’ Commonwealth Health Insurance Connector is doing its best to ensure the availability of affordable, high-quality health plans. For young adults, they’ve opted for an enhanced version of the existing student health plans, which have been mandated for almost 20 years. The plans are cheap: as low as $119 per month without drug coverage.

There’s a catch, though. The plans have annual coverage caps of $50,000 or $100,000. That’s higher than the $25,000 to $50,000 caps of the student plans, but it won’t take a seriously ill young adult (or their premature baby) to run up a bigger bill than that in Beantown.

Patricia Walrath, co-chair of the Legislature’s Health Care Financing Committee told the Boston Globe:

We thought this was one place where we could be a little experimental, because they are a very low-risk population.

But the Access Project thinks differently and issued a report critical of the plans. Plan co-author Stephen D’Amato says:

[T]he main purpose of insurance is to protect people in those rare instances when you have huge costs. Allowing these caps is duplicating a mistake that was made nearly 20 years ago. It’s going to destroy some lives


In a perfect world –or actually in any other OECD country– $119 per month would be enough to pay for comprehensive coverage for a young adult. Here, though, it isn’t. As a result, there’s a tradeoff between an affordable premium, coverage for routine services, and coverage for catastrophic costs.

I’ve written before about Mini-Meds –policies that offer limited coveraged, with caps much like these new Massachusetts plans. In some ways they are odious –almost the opposite of insurance– but they do provide access to the health care system and take away the worry of being saddled with $10,000 or $20,000 in medical debts. A debt like that can seem almost as catastrophic as a $1 million debt to people of limited income.

I don’t object to the capped plans for young adults. First, keeping the premiums somewhat reasonable will increase compliance with the mandate and increase the attractiveness of living in this state. Second, if debts get too high there’s always bankruptcy protection. Young adults have time to start over and since the hospitals will have such a high percentage of insured patients they should be able to suck up some of the losses without whining too much.



Source: HealthBusinessBlog.com

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The Senators, the FDA, the Company and The Access to Medicare Data Act of 2007

by Mark S. Senak
Eye On FDA



This year, Senators Charles Grassley (R-Iowa) and Max Baucus (D-Mont) have been on more of a tear than usual regarding the FDA. A lot of their focus this year has been on post-marketing surveillance of drugs and devices. They are concerned with drug safety, but not benefit.

In November 2006, the Breckenridge Institute issued a report that was not available to the public, but which contained an independent review of the system used by the FDA to conduct such surveillance. A partial copy of the Breckenridge report is available. Senators Grassley and Baucus issued a letter to the FDA asking that the agency account for the findings of the report.

Then in late May, Avandia hit the fandia. The Finance co-chairmen were once again in touch with the FDA sending a memorandum demanding answers about FDA's handling of Avandia. On Thursday, May 24, Senator Grassley made a statement on the floor, asking why a black box warning had not been put on Avandia by the FDA. This is despite the fact that no one knows what the effect of a black box warning really is on prescribing practices. Still, apparently, this action would have made the Senator feel better.

On Friday, the two Senators introduced new legislation - The Access to Medicare Data Act of 2007 - that would give researchers at federal agencies and university-based and other research organizations highly controlled access to data on hospital, physician and prescription drug benefits that are provided to Medicare beneficiaries. The link provides you with access to both the Grassley press release and the text of the bill, which is not yet on reporting services. Perhaps spurred by the Avandia safety issue, which also brought comment from Senator Grassley, the legislation is a re-introduction of legislation the two proposed in the 109th Congress.

By the way, GlaxoSmithKline (GSK) has set up a whole Web page about the recent cardiovascular issues associated with Avandia.

Yesterday, Dr. Scott Gottlieb, former Deputy Commissioner at FDA, current fellow at the American Enterprise Institute, and local Washington snappy dresser, had an op-ed in the Wall Street Journal (subscription required). Among other things, he said:

While there are "questions" whether Avandia is associated with certain heart risks -- so far unsupported by more rigorous, randomized studies and extensive review by the FDA and other authorities around the world -- the NEJM study doesn't add much new insight into those issues because of its own limitations... The Lancet, NEJM's British sister-publication, said of the study, "Alarmist headlines and confident declarations help nobody."


Further studies are needed to determine safety of a valuable drug, but now there will be trouble recruiting people for those studies and the market share of the product has plummeted to zero. One has to ask oneself if the hysterical reactions of many, including policy makers - who aren't medically qualified, aren't doing more harm than good as diabetes patients are asked to trade a proven benefit out of fear of an unproven risk.


Source: EyeOnFDA.com



RELATED READING:
- Compare and Contrast: EMEA and FDA on Avandia
- Networks Dramatize Diabetes Drug Dangers

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Next-Generation Psychology Treatments

by Sara Calabro
Med Tech Sentinel



An article published yesterday in Technology Review discusses two new technologies being developed to improve psychiatric treatment.

The first, from Norwood, MA-based Aspect Medical Systems (ASPM), is a device that predicts whether an antidepressant is taking effect, after just one week. Typically, patients have to wait several weeks or months for psych meds to start working. But previous research has shown that despite this delay in patient response, brain-activity — measured via electroencephalogram (EEG) — can happen after a week.

Aspect’s device, which requires only five electrodes to be placed on the patient’s head, incorporates EEG technology. It’s currently undergoing trials and so far producing positive results: At the American Psychiatric Association meeting held last week in San Diego, Aspect reported that 70-80% of the time, after one week of treatment, the device could predict if the drug would work in the longer term.

A technology not mentioned in the Review article, but one that also focuses on determining patients’ response to medications, is Referenced EEG, or rEEG, by CNS Response (CNSO.OB). With rEEG, though, the response analysis starts before the patient pops a single pill.

The technology utilizes EEG in conjunction with a normative database and a clinical (symptomatic) database to identify abnormal patient physiology. Appropriate medications are then statistically selected specifically to normalize discovered abnormalities. The process has been correlated to treatment outcomes in a database of over 1,600 patients and 10,000 medication trials. The results of the analysis for each patient are produced in a two-page report provided to the physician.

CNS Response reports that rEEG has led to positive outcomes in approximately 80% of 2000+ patients who had previously failed to respond to traditional treatment.

The other device highlighted by Technology Review is Neuronetics‘ NeuroStar, which delivers short magnetic pulses to the brain to activate cells in the targeted area. The device, designed to treat patients who are unresponsive to drugs, showed positive outcomes in a trial that concluded last year, and is now being reviewed by FDA.


Source: Med Tech Sentinel



RELATED READING:
- Neurotech Investments on the Rise
- New Device Outpaces Competition in Epilepsy Market

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Tuesday's Top Biotech & Medical Stocks

by H.S. Ayoub
BioHealth Investor.com



Biotechnology

NOVACEA, INC. [NOVC] +86.10%
CYTRX CP [CYTR] +16.24%
HEMISPHERX BIOPHARMA [HEB] +10.53%
TARGETED GENETICS CP [TGEN] +7.86%
KOSAN BIOSCIENCES [KOSN] +5.94%



Diagnostic Substances

NYMOX PHARM CORP [NYMX] +4.16%
QUIDEL CP [QDEL] +3.85%
SURMODICS INC [SRDX] +3.04%
SYNTA PHARMACEUTICAL [SNTA] +2.83%
MONOGRAM BIOSCIENCES [MGRM] +2.81%



Drug Delivery

EMISPHERE TECH [EMIS] +20.43%
DELCATH SYSTEMS INC [DCTH] +7.02%
MATRIXX INITIATVS [MTXX] +0.55%
BIOPROGRESS PLC [BPRG] +0.35%
HOSPIRA INC [HSP] +0.28%



Drug Manufacturers

NEUROLOGIX INC [NRGX.OB] +8.82%
NEURO-HITECH INC [NHPI] +5.33%
COLLAGENEX PHARM I [CGPI] +5.26%
AVANIR PHARMACEUTICL [AVNR] +4.21%
SOMAXON PHARMACEUTIC [SOMX] +3.05%



Drug Related Products

ZILA INC [ZILA] +2.96%
NATROL INC [NTOL] +2.45%
PRESTIGE BRAND HLGS [PBH] +1.87%
NUTRACEUTICAL INTL [NUTR] +1.68%
N B T Y INC [NTY] +0.54%



Generic Drugs

CARACO PHARMA LABS [CPD] +1.77%
PHARMACUTICAL CO [PRX] +0.97%
MYLAN LABS INC [MYL] +0.20%



Medical Appliances & Equipment

CHAD THERAPEUTICS [CTU] +13.47%
LECTEC CORP [LECT.OB] +10.60%
DIGIRAD CORPORATION [DRAD] +4.64%
CRYOLIFE INC [CRY] +3.86%
ENDOCARE INC [ENDO.OB] +3.64%



Medical Instruments & Supplies

NEPHROS INC. [NEP] +31.79%
VYTERIS HOLDINGS NV [VYHN.OB] +11.48%
TUTOGEN MEDICAL INC [TTG] +8.13%
ELECTRO-OPTICAL SCIE [MELA] +6.85%
MESA LABS INC [MLAB] +6.07%



Medical Laboratories & Research

SPHERIX INC [SPEX] +4.31%
ALLIANCE IMAGING INC [AIQ] +4.29%
PHARM PROD DEV [PPDI] +1.70%
GENOMIC HEALTH, INC. [GHDX] +1.51%
QUEST DIAGNOSTC [DGX] +0.66%




- Monday's Top Biotech and Medical Stocks
- Friday's Top Biotech and Medical Stocks

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Dendreon Volume and Volatility Compress Ahead of ASCO

by Jon C. Ogg
24/7 Wall St.



If you thought the day would never come that Dendreon (DNDN) would see its volatility, its hyperactive volume, and its options premium compress to something back to almost normal, guess again: it came. The stock including after-hours only traded under 5.5 million shares. The near-month June options have seen the volume dry up, and the closest call options (JUN07 $7.50 Calls) are only priced at $0.25. That is unheard of, yet this is just getting back to normal. Even its stock only saw a $0.30 trading band between the highs and the lows.

Its MAY short interest showed it to be relatively high earlier in month, but that cut-off date was before even last week. Just a week ago the stock was getting a lot of volume and interest because of some AUA data presentation (which is actually older 're-analyzed' data) and after the cost cutting and impending layoffs.


Continue article at 247WallSt.com




RELATED READING:
- Cancer Stocks on the Go: It’s ASCO
- Dendreon Interest Remains Extremely High

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Tuesday, May 29, 2007

Endocare Raises $7 Million

by Sara Calabro
Med Tech Sentinel



Endocare (ENDO.OB), an Irvine, CA-based company focused on tissue and tumor ablation, has raised $7 million in a private placement of common stock to Seattle-based Frazier Healthcare Ventures. In a statement, Endocare CEO Craig Davenport said the money will go toward the company’s development efforts in prostate and renal cancer cryoablation, and toward expanding its presence in the interventional radiology and oncology markets for lung and liver cancer, and in treating pain associated with metastases.

Endocare’s minimally invasive cryoablation procedures enable physicians to destroy tumors while leaving surrounding tissue intact. A recent study demonstrated that cryoablation as a first-line treatment for prostate cancer can be equally or more effective than radical prostatectomy or brachytherapy and eliminates the potentially toxic side effects of radioactive seeds; it’s also a lower-cost alternative to brachytherapy and radical surgery. CEO Davenport explains Endocare’s cryoablation technology and the company’s overall business model in this video.

In addition to the $7 million boost from Frazier Healthcare, Endocare still has about $14.5 million available from its previously announced agreement with Fusion Capital. In October 2006, Endocare signed a $16 million common stock purchase agreement with the Chicago-based institutional investor; Endocare also has available borrowing capacity through its existing credit facility with Silicon Valley Bank.


Source: Med Tech Sentinel




RELATED READING:
- CryoCor Raises $5.45 Million in Private Placement
- Andover Medical Closes $5.6M Private Financing

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ACI "Maximizing Pharmaceutical Patent Life Cycles" Conference

by Aaron F. Barkoff
Orange Book Blog



American Conference Institute will hold the 2nd west coast edition of its popular "Maximizing Pharmaceutical Patent Life Cycles" conference next week in San Francisco (at the beautiful Mark Hopkins hotel). ACI calls this "the only Hatch-Waxman conference specifically designed for the biopharmaceutical industry."

According to ACI, the conference will "bring the biopharmaceutical industry the critical information that it needs regarding the legal aspects of pharmaceutical patent life cycles. An esteemed faculty of biopharmaceutical industry and Hatch-Waxman experts will provide targeted information and commentary especially for biopharmas."

The following talks should be particularly interesting:

Legislative and Regulatory Update: Patents and Politics in the 110th Congress

Follow-on Biologics/Biosimilars: The IP and Political Wildcard

Aligning Product Development, Patent Portfolio Management and Patent Life Cycle Management

Eye on the Supreme Court: Key Patent Cases Before the Supreme Court and Their Impact on Pharmaceutical Patent Life Cycles

European Roche Bolar: Understanding Its Impact on U.S. Pharmaceutical Patent Life Cycles

Update on FDA Activities Relative to Pharmaceutical Patent Life Cycles

Present Controversies and Uncertainties in Market Exclusivity (by Kurt Karst of FDA Law Blog)

FTC Initiatives to Promote Competition in the Pharmaceutical Industry



Additionally, two pre- and post-conference workshops are available: "Regulatory Fundamentals and IP Basics for Small Molecules and Biologics" on June 4; and "New Strategies for Obtaining Pharmaceutical Patent Extensions" on June 7.

The co-chairs of the conference are Martin A. Voet (Sr. VP & Chief IP Counsel, Allergan, Inc. and author of The Generic Challenge) and Robert C. Funsten (Shareholder, Stradling Yocca Carlson & Rauth). Additional details and registration information are available at the conference website.

Orange Book Blog is a media partner of this conference.



Source: OrangeBookBlog.com

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Cramer's Three Biotech Picks, And His Biotech Strategy

by Jon C. Ogg
24/7 Wall St.



Jim Cramer has a video on TheStreet.com "Wall St. Confidential" showing how the biotech sector can be looked at with blow-ups. For every small biotech that grown up into a huge company there are 100 Northfield Labs (NFLD). Cramer thinks you have to play momentum and even stocks like Genentech (DNA) and Amgen (AMGN) have to be gotten out when they are no longer going up.

Cramer still likes Celgene (CELG), Gilead (GILD) and Genzyme (GENZ) in the sector. If you bet on one product wonders then have you to be prepared to lose everything. Onyx Pharma (ONXX) is a potential one-hit wonder that Cramer likes, but says to play it you should buy deep in the money calls because any bad news could chop the stock in half. He also noted that he believes the FDA is not predictable on upcoming drugs.

Continue article at 247WallSt.com



RELATED READING:
- Northfield Labs Heads Permanently South
- Cramer's Obesity Stock Plays
- Cramer's Newest Laser Pick: Cynosure

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Monday's Top Biotech & Medical Stocks

by H.S. Ayoub
BioHealth Investor.com



Biotechnology

ALFACELL CORP [ACEL] +21.60%
NOVACEA, INC. [NOVC] +13.52%
POLYDEX PHARM LTD [POLXF] +11.43%
ANTIGENICS INC [AGEN] +9.70%
NORTHFIELD LABS IN [NFLD] +7.86%



Diagnostic Substances

PRESSURE BIOSCIENC [PBIO] +10.64%
MONOGRAM BIOSCIENCES [MGRM] +8.54%
ASPENBIO PHARMA INC [APNB.OB] +7.37%
PONIARD PHARMA [PARD] +5.33%
ICAGEN, INC. [ICGN] +5.09%



Drug Delivery

EMISPHERE TECH [EMIS] +10.81%
PENWEST PHARM CO [PPCO] +5.83%
MATRIXX INITIATVS [MTXX] +2.90%
COLUMBIA LABS INC [CBRX] +2.39%
BENTLEY PHARMACEUTIC [BNT] +1.86%



Drug Manufacturers

BRADLEY PHARMACTCL [BDY] +21.20%
PHARMAXIS LTD ADR [PXSL] +6.77%
NEURO-HITECH INC [NHPI] +5.97%
PROVECTUS PHARMA [PVCT.OB] +5.49%
NEUROCHEM INC [NRMX] +5.19%



Drug Related Products

ARGAN INC [AGAX.OB] +11.20%
MANNATECH INC [MTEX] +4.02%
N B T Y INC [NTY] +3.37%
CURATECH INDUSTRIES [CUTC.OB] +3.16%
ZILA INC [ZILA] +3.05%



Generic Drugs

ISOLAGEN INC [ILE] +2.63%
CARACO PHARMA LABS [CPD] +2.08%
PHARMACUTICAL CO [PRX] +0.10%
WATSON PHARMACEUTCLS [WPI] +0.10%
MYLAN LABS INC [MYL] +0.05%



Medical Appliances & Equipment

CELSION CORP [CLN] +17.59%
SHAMIR OPTICAL INDUS [SHMR] +14.44%
MEDIS TECH LTD [MDTL] +11.59%
ENDOCARE INC [ENDO.OB] +10.55%
NORTH AMERN SCI [NASI] +6.69%



Medical Instruments & Supplies

HEMOSENSE INC. [HEM] +9.68%
APA ENTERPRISES [APAT] +7.56%
SENORX, INC. [SENO] +6.67%
BIOSPHERE MEDICAL [BSMD] +6.40%
QUANTRX BIOMEDICAL [QTXB.OB] +5.50%



Medical Laboratories & Research

NATL DENTEX CP [NADX] +3.26%
MEDTOX SCIENTFIC INC [MTOX] +2.77%
GENOMIC HEALTH, INC. [GHDX] +2.54%
RADNET INC [RDNT] +2.44%
SPHERIX INC [SPEX] +2.00%




- Friday's Top Biotech and Medical Stocks
- Thursday's Top Biotech and Medical Stocks

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Monday, May 28, 2007

Celgene Could Do Well at ASCO

by Andrew Vaino
Vaino's Biotech Corner



No matter how many times I look at Celgene’s (CELG) multiples (trailing P/E = 223 (!), P/S = 24, P/B = 11) and think it’s overpriced, the stock always moves up. This company has done phenomenally well. Initially Celgene had the foresight to develop Thalidomide (a sedative that caused birth defects) as a treatment for cancer. Celgene’s follow-on compound, Revlimid, is even better.

Celgene has been doing a great job of growing revenue and profit over the past five years. Revenue has nearly doubled each year since 2002: the company is set to easily surpass one billion this year. Operating income has doubled each year since
they became profitable (2004). Clearly, Celgene can’t continue to trade at the premium it is forever, but for now it’s a good ride.

The American Society for Cancer Oncology (ASCO) has its conference later this week in Chicago, and Celgene will be presenting new clinical data on the efficacy of Revlimid both on its own and in combination therapy. Historically CELG has always done very well as a result of the ASCO, and I think it’s safe to assume it will this year as well. To take advantage of this, and a slight softening in share price over the past week, I think this could be a good time to look into (still quite speculative) June in-the-money calls.

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GO SENS!

While investing in biotech can be fraught with risk, it’s clear to me that the NHL’s Stanley Cup Playoffs, which begin May 28th in Anaheim, are a pretty safe bet. Specifically, the Ottawa Senators will have no trouble defeating the Anaheim Ducks in five games.


Source: PeterNavarro.com



RELATED READING:
- BioWatch Alert: ArQule Could See 15% Gain Ahead of ASCO
- Celgene’s Day in Court With Barr Coming Soon
- Celgene: Phase 2 REVLIMID Data Published In Medical Journal

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Weekly Top Biotech and Medical Business Articles

by H.S. Ayoub
BioHealth Investor.com



The following articles were the most popular at BioHealth Investor for the week of May 19 - May 25.

This list can also be found on the right navigation bar of the blog during the week.



1. Thermogenesis Would Make A Great Acquisition Target

2. Networks Dramatize Diabetes Drug Dangers

3. BioWatch Alert: ArQule Could See 15% Gain Ahead of ASCO

4. Dendreon Interest Remains Extremely High

5. Congressional Hearing on FDA's Handling of Avandia




Last Week's Top Articles

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Volume Spike Investor - Live Again!

by H.S. Ayoub, DMD
BioHealth Investor.com



I just wanted to announce the return of Volume Spike Investor (VSI).

VSI is a blog that began back in 2006 to keep track of stocks experiencing price jumps on volume spikes, with no significant news. It is in fact the motivation behind the BioWatch Alert List right here at BioHealth Investor.

While the BioWatch Alert List focuses on healthcare and medical stocks, VSI does not limit itself to any particular sector or industry.

During its operation in November and December of 2006, 9 stocks made VSI's Watch Alert List. These stocks on average reached a high of about 10% within 5 days of the alert.


For more check out, VSInvestor.com


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BioWatch Alert: Strategic Diagnostics Jumps on Volume Spike

by H.S. Ayoub
BioHealthInvestor.com



Shares of Strategic Diagnostics (SDIX) jumped 4.7% on Friday as volume surged 150% more than the 3 month daily average!

There were no news or any significant events that could be detected.

Strategic Diagnostics is involved in the development, manufacture, and marketing of antibody products and analytical test kits for a range of food, water, agricultural, industrial, environmental, and scientific applications.

The company has a very tiny market cap of less than $100 million. It has about $10 million in cash and about $500 thousand in debt according to the latest Yahoo! financial data.

Shares of SDIX closed at $4.90 on Friday, which is about 10% below the 52-week high of $5.40 reached back in April.

Strategic Dianostics has made BHI's BioWatch Alert List, and will be tracked for the next two weeks.



Source: BioHealthInvestor.com
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Sunday, May 27, 2007

Cancer Stocks on the Go: It’s ASCO

by Alan Brochstein, CFA
Analyst For Hire



Later this week, the big event of the year for companies trying to treat cancer takes place in Chicago: the American Society of Clinical Oncology’s Annual Meeting. Not surprisingly, the universe of cancer stocks performed well in a rather lackluster week for the market. I recently created a list of companies with market capitalization in excess of $50mm at the beginning of May that derive a significant amount of their market value from cancer-related pursuits. The group includes primarily biotech companies seeking cures, but it also has diagnostic and other types of treatment companies. I ask the reader to please let me know if there are any omissions or erroneous inclusions. Here is the list, ranked on price performance over the past week:


As you can see, the median and mean returns were slightly positive despite the pullback in the market. Looking at the extreme moves, there were 7 stocks that rallied in excess of 10%, while 4 fell in excess of 10%. Bioenvision (BIVN) led the way, improving on an increased investment by Soros earlier this month and an article on businessweek.com that blasted the stock through resistance just under $5. Neose (NTEC) received a milestone payment and gained a new patent. Motley Fool had a nice write-up as well. Cytyc (CYTC) agreed to be acquired by Hologic (HOLX), which almost made the double-digit-down list. IDM Pharma (IDMI) rose on top of an upgrade from Cantor Fitzgerald. Micromet (MITI) signed a big deal with Nycomed. Sonus (SNUS) didn’t appear to have any specific news, but the stock is approaching a 3yr-high as it awaits Phase 2 results on a drug that improves upon popular breast cancer treatment, Paclitaxel. Inovio (INO) sold 4.5mm shares at 3.52 and provided positive data on one of its drugs under development.

As far as the losers, Vion (VION) halted a Phase 3 ALL trial, indicating the risks of investing in these speculative companies. Molecular Insight (MIPI) is a recent IPO trading below its initial price of 14. Curis (CRIS) is down big this month but still positive on the year. The company has reported terminations in development agreements with two companies this month. Finally, Zila (ZILA) was forced by its lenders to replace the Chairman of the Board, who remains the CEO.


Source: AnalystForHire.com




RELATED READING:
- BioWatch Alert: ArQule Could See 15% Gain Ahead of ASCO
- Is Early Release of Study Data to Doctors Unfair?

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Saturday, May 26, 2007

IBD Weekly Top Ranked Medical Stocks

The following list represents the top ten medical stocks ranked according to Earnings Per Share and Relative Strength by Investor's Business Daily (5/26/07)


scores out of 100 (last week's rank, change in score):

1(1) Medtox Scientific (MTOX) EPS=99 RS=99
2(3) Cynosure (CYNO) EPS=97 RS=98(+1)
3(2) Rochester Medical (ROCM) EPS=99 RS=93(-2)
4(4) Span Amer Med Sys (SPAN) EPS=91 RS=98(-1)
5(7) Celgene (CELG) EPS=99 RS=90(+1)
6(5) Wellcare (WCG) EPS=96 RS=92(-2)
7(8) Stratagene (STGN) EPS=92(-1) RS=95(+1)
8(10) American Orient Bioeng (AOB) EPS=94 RS=93(+1)
9(9) Almost Family (AFAM) EPS=90 RS=96
10(-) Cytyc Corp (CYTC) EPS=91 RS=95



- May 19; IBD Weekly Top Ranked Medical Stocks
- May 12; IBD Weekly Top Ranked Medical Stocks
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